Molecular Mechanisms of Induced Pluripotency
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of induced pluripotency
Growing knowledge concerning transcriptional control of cellular pluripotency has led to the discovery that the fate of differentiated cells can be reversed, which has resulted in the generation, by means of genetic manipulation, of induced pluripotent stem cells. Overexpression of just four pluripotency-related transcription factors, namely Oct3/4, Sox2, Klf4, and c-Myc (Yamanaka factors, OKSM...
متن کاملMolecular Mechanisms of Induced Pluripotency
In this review the distinct aspects of somatic cell reprogramming are discussed. The molecular mechanisms of generation of induced pluripotent stem (iPS) cells from somatic cells via the introduction of transcription factors into adult somatic cells are considered. Particular attention is focused on the generation of iPS cells without genome modifications via the introduction of the mRNA of tra...
متن کاملMolecular Mechanisms Underlying Pluripotency
Pluripotency and self renewal are the two primary characteristics of pluripotent stem cells (PSCs) [1]-[4]. Pluripotency refers to the capacity of a single cell to give rise to any cell type of an embryo or an adult animal [5],[6]. A mammalian organism is developed from a single fertilized egg, the zygote, in an extremely ordered and error-proof fashion [7]. The zygote and the subsequent 2 to 4...
متن کاملStochasticity and the Molecular Mechanisms of Induced Pluripotency
The generation of induced pluripotent stem cells from adult somatic cells by ectopic expression of key transcription factors holds significant medical promise. However, current techniques for inducing pluripotency rely on viral infection and are therefore not, at present, viable within a clinical setting. Thus, there is now a need to better understand the molecular basis of stem cell pluripoten...
متن کاملEpigenetic mechanisms of induced pluripotency
Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) requires profound alterations in the epigenetic landscape. During reprogramming, a change in chromatin structure resets the gene expression and stabilises self-renewal. Reprogramming is a highly inefficient process, in part due to multiple epigenetic barriers. Although many epigenetic factors have already been shown to aff...
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ژورنال
عنوان ژورنال: Acta Naturae
سال: 2012
ISSN: 2075-8251
DOI: 10.32607/20758251-2012-4-1-12-22